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CGRP Recombinant Rabbit mAb (SDT-2490-75)

Calcitonin gene-related peptide 1,CGRP1

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货号 S0B3619
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产品介绍

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产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    CGRP

  • 分子别名

    Calcitonin gene-related peptide 1; CGRP1

  • 免疫原

    Synthetic Peptide

  • Accession

    P06881

  • 克隆号

    SDT-2490-75

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 交叉反应

    It reacts with both α-CGRP and β-CGRP

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt, 2 to 8 °C as supplied

  • 应用

    Sandwich ELISA

背景介绍

  • CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by tissue-specific splicing of the CALCA gene in primary afferent sensory neurons and central neurons; it signals through a heterodimeric receptor composed of the G-protein-coupled receptor CALCRL and the accessory protein RAMP1, potently dilating cerebral and dermal vasculature, modulating nociceptive transmission, and mediating neuro-inflammatory responses, making it a key target for monoclonal antibodies and small-molecule antagonists in the prevention of migraine and the treatment of cluster headache.

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