PACAP Recombinant Rabbit mAb (SDT-2454-48)

PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a neuropeptide widely distributed in the nervous and endocrine systems. It functions as a potent neurotransmitter, neuromodulator, and vasodilator, playing crucial roles in stress response, metabolism, and cerebral blood flow regulation. Detection of PACAP holds significant clinical and research value. It is primarily measured in plasma or cerebrospinal fluid using immunoassays like ELISA. Its major significance lies in its strong association with primary headache disorders, particularly migraine. PACAP levels can serve as a potential biomarker for migraine pathophysiology, aiding in understanding attack mechanisms and evaluating treatment efficacy, especially for emerging PACAP-targeted therapies. Furthermore, its detection supports research into its roles in other conditions like inflammation, psychiatric disorders, and metabolic diseases.