Presepsin Recombinant Rabbit mAb (SDT-2138-29)

The soluble cluster of differentiation 14 subtype, presepsin, is a novel and promising biomarker identified in 2005. Presepsin is a soluble N-terminal fragment of the cluster of differentiation (CD) marker protein CD14. CD14 is a free fragment of glycoprotein expressed on monocyte and macrophage. It is a receptor of lipopolysaccharide–lipopolysaccharide-binding protein (LPS-LBP) complexes, transducing the endotoxin signal from bacterial infection through the Toll-like receptor-4. Its soluble form, soluble CD14 (sSD14), is produced from cell secretion or when membrane-bound, CD14 (mCD14) detaches from cells such as phagocytes. The N-terminal fragments of 13 kDa consist of sCD14 subtype (sCD14-ST; presepsin) are related to mediating the immune response to LPS. PCT level increases in 8–24 h and reaches the peak later than 24 h after infection, while presepsin level typically increases within 2 h and reaches the peak in 3 h. Presepsin was reported to have diagnostic and prognostic abilities in patients with sepsis in some studies performed according to the previous Sepsis-2 definitions. A systematic review and meta-analysis showed that the diagnostic accuracy of presepsin in detecting infection was similar to that of PCT, and both biomarkers were useful for the early diagnosis of sepsis.