CD25/IL-2R alpha Recombinant Rabbit mAb (SDT-161-293)

IL-2RA, also known as ICD25, is the alpha chain of the interleukin-2 receptor, a heterotrimeric protein complex that also includes beta (IL2RB) and the common gamma chain (IL2RG). It is a membranous glycoprotein primarily expressed on activated T lymphocytes and plays a crucial role in immune homeostasis by interacting with interleukin-2, a pleiotropic cytokine. CD25 is involved in the proliferation of T and B lymphocytes and is essential for the assembly of the high-affinity interleukin-2 receptor. In addition to its role in the immune system, CD25 is also expressed on certain non-immune cells and has been identified as a potential therapeutic target in cancers. A soluble form of IL-2 R alpha can be generated by proteolytic cleavage of the cell surface receptor. In any case, increased levels of the soluble IL-2RA in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Results of a number of studies suggest a correlation of levels of IL-2 Rα in serum with the onset of rejection episodes in allograft recipients, with activity of autoimmune diseases.