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Rabbit抗原名称
Lp-PLA2分子别名
PLA2G7免疫原
Recombinant ProteinAccession
Q13093克隆号
SDT-972-303抗体类型
Recombinant mAb抗体同种型
IgG应用
Sandwich ELISA反应种属 ?
Hu交叉反应
No cross reactivity against Apolipoprotein A-I, Apolipoprotein E
纯化方式
Protein A浓度
2 mg/ml纯度
＞95% by HPLC标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt, 2 to 8 °C as supplied
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as plasma platelet-activating factor acetylhydrolase, is an enzyme encoded by the PLA2G7 gene and belongs to the phospholipase A2 superfamily. It is primarily associated with lipoproteins in the bloodstream and plays a crucial role in lipid metabolism and inflammation. Lp-PLA2 hydrolyzes oxidized phospholipids, such as oxidized low-density lipoprotein (oxLDL), into lysophosphatidylcholine and non-esterified fatty acids, contributing to the progression of atherosclerosis. Additionally, Lp-PLA2 (Lipoprotein-associated phospholipase A2) serves as a biomarker for vascular inflammation and atherosclerosis. It is specifically expressed in atherosclerotic plaques and associated with plaque instability. Elevated Lp-PLA2 levels independently predict increased risk of cardiovascular events (e.g., heart attack, stroke), particularly in individuals without traditional risk factors. While not diagnostic for specific diseases, it aids in risk stratification and may guide targeted preventive therapies.
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