TNF alpha Recombinant Rabbit mAb (SDT-127-222)
TNF-alpha,Tumor necrosis factor,Cachectin,Tumor necrosis factor ligand superfamily member 2,TNF-a,TNF,TNFA,TNFSF2,TNF-α,TNFα,TNF alpha,TNFalpha,Tumor necrosis factor ligand superfamily member 2 (TNF-a)
货号： S0B3318
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Rabbit抗原名称
TNF alpha分子别名
Tumor necrosis factor; Cachectin; Tumor necrosis factor ligand superfamily member 2 (TNF-a); TNFA; TNFSF2免疫原
Recombinant Protein细胞定位
SecretedAccession
P01375克隆号
SDT-127-222抗体类型
Recombinant mAb抗体同种型
IgG应用
Sandwich ELISA反应种属 ?
Hu交叉反应
Does not recognize CD40, TNF-beta纯化方式
Protein A浓度
2 mg/ml纯度
>95% by HPLC标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
Tumor Necrosis Factor-alpha (TNF-α) is a homotrimeric protein consisting of 157 amino acids and serves as a potent pro-inflammatory cytokine. It plays a crucial role in various biological functions, including immune responses, inflammatory processes, cell growth, and apoptosis, by binding to its receptors TNFR1 and TNFR2. The dysregulation of TNF-α is associated with a multitude of diseases, such as autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis, ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. In the treatment of autoimmune diseases, TNF-α inhibitors have become an essential therapeutic strategy, with examples including infliximab, etanercept, and adalimumab. In the context of in vitro diagnostic (IVD) applications, TNF-α is often measured in the blood to assess inflammatory responses across a broad spectrum of diseases.
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