Canine Pancreatic Lipase Recombinant Rabbit mAb (SDT-803-38)

As is the case in humans, pancreatitis is the most common disease of the exocrine pancreas in dogs and cats. Pancreatic histopathology was traditionally considered the gold standard for diagnosing pancreatitis, but it is rarely performed antemortem in veterinary clinical practice. This is due to its invasiveness and high costs in addition to other inherent limitations, such as the potential to miss localized pancreatic lesions and detection of abnormalities that may be clinically irrelevant. Therefore, the diagnosis of pancreatitis in dogs and cats is often based on an overall assessment of clinical data, including history, clinical signs, physical examination findings, and clinicopathologic and diagnostic imaging findings in addition to measurement of pancreatic lipase concentrations or activity in serum or plasma. Under normal physiologic conditions, the vast majority (approx 99%) of pancreatic lipase and colipase is released from the apical pole of the pancreatic acinar cell into the pancreatic juice for subsequent digestion of dietary fat. Less than 1% diffuses from the basolateral aspect of the acinar cells into circulation. However, when the pancreas is inflamed, apical secretion is blocked and a large amount of pancreatic lipase is released into the vascular space via the basolateral aspect of the cell. Therefore, measurement of pancreatic lipase in circulation can be used as a noninvasive diagnostic marker for acinar cell inflammation or damage during pancreatitis. (PMID: 35943918)