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Rabbit分子别名
Kidney injury molecule 1 (KIM-1), T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1), T-cell immunoglobulin mucin receptor 1 (TIM; TIM-1), T-cell membrane protein 1免疫原
Recombinant ProteinAccession
Q96D42克隆号
SDT-932-55抗体类型
Recombinant mAb抗体同种型
IgG应用
Sandwich ELISA, Lateral Flow反应种属 ?
Hu交叉反应
Does not recognize TIM-3, TIM-4纯化方式
Protein A浓度
2 mg/ml纯度
>95% by HPLC标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300储存条件
12 months from date of receipt, 2 to 8 °C as supplied
Preclinical subtractive hybridization screens identified kidney injury molecule 1 (Kim-1) as a gene that is markedly up-regulated in ischemic rat kidneys. Downstream proteomic studies have also shown KIM-1 to be one of the most highly induced proteins in the kidney after AKI in animal models. KIM-1 is a transmembrane protein that is not expressed in normal kidney but is specifically upregulated in dedifferentiated proximal tubule cells after ischemic or nephrotoxic AKI. It has been identified as a phosphatidylserine receptor that transforms epithelial cells into phagocytes by recognizing cell surface-specific epitopes expressed by apoptotic tubular epithelia. A proteolytically processed extracellular domain of KIM-1 is detectable in the urine soon after AKI. KIM-1 represents a promising biomarker for the early diagnosis of AKI and its clinical outcomes. The recent availability of a rapid urine dipstick test for KIM-1 will facilitate its further evaluation in preclinical and clinical studies.
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