Wnt-3a Recombinant Rabbit mAb (SDT-179-112)

Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues. Wnt3a plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation. Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.