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产品中心 抗体 病理/IHC抗体

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PF4 Recombinant Rabbit mAb (SDT-4218)

Platelet factor 4,PF-4,C-X-C motif chemokine 4,Iroplact,Oncostatin-A,CXCL4,SCYB4

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B2470
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    PF4

  • 分子别名

    Platelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; CXCL4; SCYB4

  • 细胞定位

    Secreted

  • Accession

    P02776

  • 克隆号

    SDT-4218

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    0.25 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    IHC-P ?

  • 稀释度

    应用 稀释度 推荐种属
    IHC-P 1:1000 Hu
背景介绍

  • Platelet factor 4 (PF4) is a 70–amino-acid, 7.8-kDa CXC chemokine stored in platelet α-granules and released upon activation, where it binds glycosaminoglycans such as heparin with ultra-high affinity, neutralizes the anticoagulant activity of heparin by bridging and clustering it on platelet or endothelial surfaces, and forms stable tetramers that can subsequently assemble into ultra-large immune complexes recognized by anti-PF4/heparin antibodies in heparin-induced thrombocytopenia (HIT), while also exerting broader immune-modulatory effects by recruiting and activating leukocytes, promoting neutrophil extracellular trap (NET) formation, enhancing monocyte adhesion and phagocytosis, and amplifying thrombo-inflammation in conditions such as sepsis, COVID-19, and atherosclerosis through interaction with receptors including CXCR3, TLR4, and FcγRIIA.

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human spleen. Anti-PF4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human placenta. Anti-PF4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human cervical squamous cell carcinoma. Anti-PF4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of PF4 in tumor tissue.

    • Expression of PF4 in human tissue.

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