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产品中心 抗体 病理/IHC抗体

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P2ry12 Recombinant Rabbit mAb,PBS Only (SDT-3134-52)

P2Y purinoceptor 12,P2Y12,ADP-glucose receptor (ADPG-R),P2T(AC),P2Y(AC),P2Y(cyc),P2Y12 platelet ADP receptor (P2Y(ADP)),SP1999,HORK3,P2RY12

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货号 S0B2460P
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    P2ry12

  • 分子别名

    P2Y purinoceptor 12; P2Y12; ADP-glucose receptor (ADPG-R); P2T(AC); P2Y(AC); P2Y(cyc); P2Y12 platelet ADP receptor (P2Y(ADP)); SP1999; HORK3; P2RY12

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Cell membrane

  • Accession

    Q9H244

  • 克隆号

    SDT-3134-52

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    0.1 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS

  • 储存条件

    12 months from date of receipt / reconstitution, 4 °C as supplied

  • 应用

    IHC-P ?

  • 稀释度

    应用 稀释度 推荐种属
    IHC-P 1:1000 Hu
背景介绍

  • P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) is a 22 kDa Gαi-coupled seven-transmembrane receptor that is best known as the primary platelet receptor for ADP, where it triggers Rap1- and αIIbβ3 integrin-dependent aggregation and is the target of widely used antithrombotic drugs such as clopidogrel; beyond hemostasis, the same receptor is expressed on osteoclasts, microglia, vascular smooth-muscle cells and certain neurons, mediating ADP-evoked bone resorption, microglial chemotaxis and synaptic pruning, foam-cell formation in atherosclerosis, and neuroinflammatory responses that can either exacerbate or protect against neurodegeneration depending on context.

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-P2ry12 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • Negative control: IHC shows negative staining in paraffin-embedded human liver. Anti-P2ry12 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human glioblastoma. Anti-P2ry12 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of P2ry12 in tumor tissue.

    • Expression of P2ry12 in human tissue.

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