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产品中心 抗体 病理/IHC抗体

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VSIG4 Recombinant Rabbit mAb (SDT-2737-61)

V-set and immunoglobulin domain-containing protein 4,Protein Z39Ig,CRIg,Z39IG

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B2438
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    VSIG4

  • 分子别名

    V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; CRIg; Z39IG

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Membrane

  • Accession

    Q9Y279

  • 克隆号

    SDT-2737-61

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 阳性样本

    THP-1

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    IHC-P ?

    WB

  • 稀释度

    应用 稀释度 推荐种属
    WB 1:1000 Hu
    IHC-P 1:1000 Hu
背景介绍

  • VSIG4 (V-set and immunoglobulin domain-containing 4), also known as CRIg, is a transmembrane glycoprotein of the B7-related family that is selectively expressed on resting tissue macrophages; it functions both as a potent negative regulator of T-cell activation and IL-2 production and as a complement receptor that binds C3b/iC3b-opsonized particles, thereby mediating rapid phagocytic clearance of pathogens while inhibiting the alternative complement pathway convertase to limit inflammation and maintain peripheral immune tolerance.

  • 免疫印迹

    • WB result of VSIG4 Recombinant Rabbit mAb
      Primary antibody: VSIG4 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: Jurkat whole cell lysate 20 µg
      Lane 2: THP-1 whole cell lysate 20 µg
      Negative control: Jurkat whole cell lysate
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 44 kDa
      Observed MW: 55 kDa
      This blot was developed with high sensitivity substrate

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human colon. Anti-VSIG4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human kidney. Anti-VSIG4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human liver. Anti-VSIG4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human spleen. Anti-VSIG4 antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of VSIG4 in tumor tissue.

    • Expression of VSIG4 in human tissue.

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