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CFTR Recombinant Rabbit mAb ,PBS Only(SDT-2133-154)

Cystic fibrosis transmembrane conductance regulator,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel,ABCC7

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货号 S0B2398P
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产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    CFTR
  • 分子别名

    Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; ABCC7
  • 免疫原

    Synthetic Peptide
  • 细胞定位

    Cell membrane, Endoplasmic reticulum membrane
  • Accession

    P13569
  • 克隆号

    SDT-2133-154
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 反应种属 ?

    Hu
  • 阳性样本

    Human pancreas
  • 纯化方式

    Protein A
  • 浓度

    1mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS

  • 储存条件

    12 months from date of receipt / reconstitution, 4 °C as supplied

  • 应用

    IHC-P ?

  • 稀释度

    应用 稀释度 推荐种属
    IHC-P 1:250 Hu
背景介绍
  • The CFTR protein, or cystic fibrosis transmembrane conductance regulator protein, is a crucial membrane protein found primarily in epithelial cells lining various organs such as the lungs, pancreas, and sweat glands. It functions as a chloride channel, regulating the movement of chloride ions across cell membranes to maintain proper fluid balance and mucus consistency. Mutations in the CFTR gene can lead to cystic fibrosis, a genetic disorder characterized by thick, sticky mucus buildup in the lungs and digestive system, causing chronic infections and impaired organ function. The CFTR protein also plays a role in regulating sodium channels and has broader implications for epithelial cell function and ion transport.

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human pancreas. Anti-CFTR antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

  • 组织表达图谱

    • Expression of CFTR in tumor tissue.

    • Expression of CFTR in human tissue.

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