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ErbB3 Recombinant Rabbit mAb (SDT-991-73-2)

Receptor tyrosine-protein kinase erbB-3,Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3,HER3

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B2336
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    ERBB3

  • 分子别名

    Receptor tyrosine-protein kinase erbB-3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, HER3

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Cell membrane

  • Accession

    P21860

  • 克隆号

    SDT-991-73-2

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

  • 应用

    IHC-P ?

    WB

  • 稀释度

    应用 稀释度
    WB 1:1000
    IHC-P 1:200-1:500
背景介绍

  • HER3/ERBB3 is a member of the family of ERBB receptor protein tyrosine kinase family, but lacks tyrosine kinase activity. The phosphoric acidization of ERBB3 depends on the combination of other ERBB tyrosine kinase. When combined with ligands, an heterodimers is formed between ERBB3 and other ERBB proteins. ERBB3 is widely expressed in human adult tissues, including cells of the gastrointestinal, urinary, respiratory, reproductive tracts, skin, endocrine and nervous systems. ERBB3 is highly expressed in many cancer cells, such as breast, ovarian, lung, colorectal, melanoma, head and neck, cervical and prostate cancers.

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human breast. Anti- ErbB3 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human tonsil. Anti- ErbB3 antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

    • IHC shows positive staining in paraffin-embedded human breast cancer. Anti- ErbB3 antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

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