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Biotin Mouse Anti-Human CD16 Antibody (S-R440)

Low affinity immunoglobulin gamma Fc region receptor III-A,IgG Fc receptor III-A,CD16-II,CD16a antigen,Fc-gamma RIII-alpha (Fc-gamma RIII,Fc-gamma RIIIa,FcRIII,FcRIIIa,FcgammaRIIIA),FcR-10,IgG Fc receptor III-2,CD16A,FCGR3A

货号： S0B1822

Datasheet COA
  • 价格： ￥600
  • 规格：
  • 数量：
斯达特大包装询价 大包装询价

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD16

  • 分子别名

    Low affinity immunoglobulin gamma Fc region receptor III-A; IgG Fc receptor III-A; CD16-II; CD16a antigen; Fc-gamma RIII-alpha (Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcgammaRIIIA); FcR-10; IgG Fc receptor III-2; CD16A; FCGR3A

  • 细胞定位

    Cell membrane, Secreted

  • Accession

    P08637

  • 克隆号

    S-R440

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG1,k

  • 应用

    FCM

  • 反应种属 ?

    Hu

  • 阳性样本

    Human PBMC

  • 纯化方式

    Protein G

  • 浓度

    0.2 mg/ml

  • 标记

    Biotin

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

稀释度
应用 稀释度 推荐种属
FCM 1.25μl per million cells in 100μl volume Hu
背景介绍

  • CD16, also known as FcγRIII, is a low-affinity IgG receptor expressed on various immune cells, including natural killer (NK) cells, monocytes, macrophages, and neutrophils. As a member of the immunoglobulin superfamily, CD16 plays a crucial role in immune responses by binding to the Fc portion of IgG antibodies. This interaction triggers several important immune functions such as phagocytosis, respiratory burst, and antibody-dependent cellular cytotoxicity (ADCC), which are vital for defending against pathogens and cancer cells. CD16 exists in two forms, CD16a and CD16b, with CD16a being predominantly found on NK cells and monocytes, while CD16b is primarily expressed on neutrophils. Its ability to activate NK cells and enhance their cytotoxicity against target cells makes CD16 a significant target in cancer immunotherapy and antibody drug development.

  • 流式分析

    • Flow cytometric analysis of Human CD16 expression on human peripheral blood. Human peripheral blood was stained with biotin Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD11a antibody (Right panel) at 1.25μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.

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