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宿主来源
Rabbit抗原名称
Lamin A/C分子别名
Prelamin-A/C; 70 kDa lamin, Renal carcinoma antigen NY-REN-32; LMN1; LMNA细胞定位
NucleusAccession
P02545克隆号
SDT-R041抗体类型
Recombinant mAb抗体同种型
IgG应用
WB反应种属 ?
Hu阳性样本
HeLa, HUVEC, HepG2纯化方式
Protein A浓度
2 mg/ml标记
HRP性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:5000-1:10000 | Hu |
Lamin A/C is a crucial nuclear protein encoded by the LMNA gene, playing a significant role in maintaining the structural integrity of the cell nucleus. It is part of the nuclear lamina, a fibrous layer that provides support to the nuclear envelope and helps in organizing the chromatin. Beyond its structural function, lamin A/C is involved in various cellular processes, including gene regulation, DNA replication and repair, cell differentiation, and mechanosensing. Mutations in the lamin A/C gene can lead to a range of diseases collectively known as laminopathies, which include muscular dystrophy, lipodystrophy, and certain forms of cardiomyopathy. Additionally, lamin A/C has been implicated in cancer, where its deregulation can contribute to genomic instability and affect the mechanical resilience of tumor cells.
免疫印迹
WB result of Lamin A/C Recombinant Rabbit mAb (HRP Conjugate)
Primary antibody: Lamin A/C Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
Lane 1: HeLa whole cell lysate 20 µg
Lane 2: HUVEC whole cell lysate 20 µg
Lane 3: HepG2 whole cell lysate 20 µg
Predicted MW: 64, 74 kDa
Observed MW: 60, 74 kDa
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