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宿主来源
Mouse抗原名称
CD105分子别名
Endoglin; ENG; END免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P17813克隆号
S-837-10抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
Jurkat纯化方式
Protein A浓度
0.2mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5 μl per million cells in 100μl volume Hu
Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. Endoglin has been found to be an auxiliary receptor for the TGF-beta receptor complex. It thus is involved in modulating a response to the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, BMP-7 and BMP-9. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type 1.
流式分析
Flow cytometric analysis of Human CD105 expression on HeLa cells. Cells from the HeLa (Human cervix adenocarcinoma epithelial cell, Left) or Jurkat (Human T cell leukemia T lymphocyte, Right) cell line was stained with SDT PerCP-Cy5.5 Mouse Anti-Human CD105 antibody (Red line histogram) at 5 μl/test, cells without incubation with primary antibody and secondary antibody (Black line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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