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宿主来源
Rat抗原名称
CD83分子别名
CD83 antigen; mCD83细胞定位
Cell membraneAccession
O88324克隆号
S-R522抗体类型
Rat mAb抗体同种型
IgG1,k应用
FCM反应种属 ?
Ms阳性样本
Mouse splenocytes treated with LPS纯化方式
Protein G浓度
0.1 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Ms |
CD83 is a member of the immunoglobulin superfamily, expressed in both membrane-bound and soluble forms. It is most highly and stably expressed by mature dendritic cells (DCs), playing a critical role in their maturation, activation, and homeostasis. CD83 is not a typical co-stimulatory molecule but rather a key factor in controlling and resolving immune responses. It is essential during the differentiation of T and B lymphocytes and the development and maintenance of tolerance. The membrane-bound form of CD83 (mCD83) is found on various activated immune cells, while soluble CD83 (sCD83) is elevated in the serum of patients with autoimmune diseases and some hematological malignancies, exhibiting immune suppressive functions. CD83's interaction partners and signaling pathways remain not fully understood, but it is emerging as a promising immune modulator with therapeutic potential in conditions such as autoimmune disease, graft-vs.-host disease, transplantation, and hematological malignancies.
流式分析
Mouse splenocytes treated with 10 μg/ml LPS for 4h (Right panel) or untreated (Left panel) labelling SDT FITC Rat Anti-Mouse CD83 Antibody at 0.5 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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