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宿主来源
Mouse抗原名称
CD42b分子别名
GPIb, Platelet glycoprotein Ib alpha chain; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha免疫原
Recombinant Protein细胞定位
MembraneAccession
P07359克隆号
S-935-7抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
0.4 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5 μl per million cells in 100μl volume Hu
Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. Glycoprotein Ib (GPIb) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The GpIb functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis.
流式分析
Flow cytometric analysis of Human CD42b expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with APC Mouse Anti-Human CD41 antibody and either FITC Rat IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD42b Antibody (Right panel) at 2 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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