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宿主来源
Rat抗原名称
CD8α分子别名
Lyt-2免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P01731克隆号
S-353-45抗体类型
Rat mAb抗体同种型
IgG1,λ应用
FCM反应种属 ?
Ms阳性样本
BALB/c mouse splenocytes纯化方式
Protein G浓度
0.1mg/ml标记
Alexa Fluor® 700性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Ms |
CD8a, also known as CD8α, is a molecular marker on the surface of T lymphocytes. It belongs to the family of leukocyte differentiation antigens and is primarily expressed on the surface of cytotoxic T lymphocytes (CTLs). CD8a plays a crucial role in immune responses related to cytotoxicity and local inflammation. It has the ability to bind to MHC class I molecules. The expression level of CD8 molecules undergoes changes during various stages of T cell differentiation, development, and in response to T cell stimuli. Additionally, CD8a is closely associated with autoimmune monitoring, humoral immune responses, and transplant reactions. For instance, CD8a can serve as a monitoring indicator for certain autoimmune diseases and plays a significant role in immunotherapy for anti-tumor and anti-viral treatments.
流式分析
- Multiparameter flow cytometric analysis of Mouse CD8α expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD3 antibody and either Alexa Fluor® 700 Mouse IgG1, λ Isotype Control (Left panel) or SDT Alexa Fluor® 700 Rat Anti- Mouse CD8α antibody (Right panel) at 0.5 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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