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FITC Rabbit Anti-Mouse NK1.1/CD161 Antibody (S-428-32)

Killer cell lectin-like receptor subfamily B member 1C,CD161 antigen-like family member C,Lymphocyte antigen 55c (Ly-55c),NKR-P1.9,NKR-P1C,Natural killer cell surface protein P1-40 (NKR-P1 40),CD161c,Klrb1c

货号： S0B1657

Datasheet COA
  • 价格： ￥650
  • 规格：
  • 数量：
斯达特大包装询价 大包装询价

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    NK1.1/CD161

  • 分子别名

    Killer cell lectin-like receptor subfamily B member 1C; CD161 antigen-like family member C; Lymphocyte antigen 55c (Ly-55c); NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40 (NKR-P1 40); CD161c; Klrb1c

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Membrane

  • Accession

    P27814

  • 克隆号

    S-428-32

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 应用

    FCM

  • 反应种属 ?

    Ms

  • 阳性样本

    C57BL/6 mouse splenocytes

  • 纯化方式

    Protein A

  • 浓度

    0.02mg/ml

  • 标记

    FITC

  • 性状

    Liquid

  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
稀释度
应用 稀释度 推荐种属
FCM 5 μl per million cells in 100μl volume Ms
背景介绍

  • CD161 is a C-type lectin-like membrane receptor expressed at high levels on NK, NKT, Th17, Mucosa Associated Invariant T cells (MAITs), non-MAIT CD8+, tissue-resident memory cells (TRMs), αβ CD4+ T cells and CD8+ T cells. CD161 levels increase when αβ T cells enter tissues. The ligand for CD161 is the lectin-like transcript 1 (LLT1). CD161/LLT1 engagement inhibits NK cell function but can inhibit or enhance αβ T cell function depending on the co-stimulatory molecules involved. The inhibitory capacity of αβ T cells can be neutralized by blocking CD161. CD161 expression on γδ T cells is associated with enhanced IFN-γ and IL-17 production and enhanced endothelial transmigration.

  • 流式分析

    • Multiparameter flow cytometric analysis of Mouse NK1.1/CD161 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Phycoerythrin Rat Anti-Mouse CD49b antibody and either FITC Rabbit IgG Isotype Control (Left panel) or SDT FITC Rabbit Anti-Mouse NK1.1/CD161 antibody (Right panel) at 0.1 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.

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