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宿主来源
Mouse抗原名称
CD127分子别名
Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127细胞定位
Cell membraneAccession
P16871克隆号
S-R462抗体类型
Mouse mAb抗体同种型
IgG1,k应用
FCM反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Hu |
CD127, also known as the interleukin-7 receptor alpha chain (IL-7Rα) or simply the IL-7 receptor, is a transmembrane glycoprotein primarily expressed on the surface of T cells, B cells, natural killer (NK) cells, as well as certain hematopoietic stem cells and progenitor cells. Upon binding to IL-7, CD127 activates a series of signaling pathways, including the JAK-STAT cascade, which subsequently promotes the growth and differentiation of lymphocytes. This interaction is particularly crucial during the development of T and B cells within the thymus and bone marrow, as it aids in their progression from early progenitor stages to maturity. Furthermore, the expression level of CD127 serves as an indicator for assessing lymphocyte function and status.
流式分析
Multiparameter flow cytometric analysis of Human CD127 expression on human peripheral blood mononuclear cell populations. Human peripheral blood mononuclear cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 antibody and either FITC Mouse IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD127 antibody (Right panel) at 1 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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