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宿主来源
Mouse抗原名称
CD27分子别名
CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7免疫原
Recombinant Protein细胞定位
MembraneAccession
P26842克隆号
S-568-1抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu纯化方式
Protein G浓度
0.2mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 FCM 5 μl per million cells in 100μl volume
CD27 is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T cells and natural killer (NK) cells, with lower expression levels found on B cells, monocytes, and dendritic cells. CD27 plays a significant role in regulating immune responses. Specifically, CD27 interacts with its ligand, CD70 (also known as TNFSF7 or tumor necrosis factor ligand superfamily member 7), participating in intercellular signaling. This interaction is crucial for the proliferation, survival, and differentiation of T cells and NK cells. Furthermore, the CD27-CD70 interaction is also involved in the activation, proliferation, and antibody production of B cells.
流式分析
- Flow cytometric analysis of Human CD27 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 antibody and either FITC Mouse IgG1, κ Isotype Control (Left panel) or SDT FITC Mouse Anti-Human CD27 Antibody (Right panel) at 1 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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