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ABCA1 Recombinant Rabbit mAb (S-1887-25)

Phospholipid-transporting ATPase ABCA1,ATP-binding cassette sub-family A member 1,ATP-binding cassette transporter 1 (ABC-1,ATP-binding cassette 1),Cholesterol efflux regulatory protein,ABC1,CERP

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1471

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

ABCA1
分子别名

Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1 (ABC-1; ATP-binding cassette 1); Cholesterol efflux regulatory protein; ABC1; CERP
免疫原

Synthetic Peptide
细胞定位

Endosome, Cell membrane
Accession

O95477
克隆号

S-1887-25
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
阳性样本

HepG2, U-87 MG, mouse liver, rat brain
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms, Rt

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms, Rt

背景介绍

ABCA1 (ATP Binding Cassette Subfamily A Member 1) is a protein encoded by the ABCA1 gene, located on chromosome 9q31.1. It is a member of the ATP-binding cassette (ABC) transporter family, which uses energy from ATP hydrolysis to transport various substrates across cell membranes. ABCA1 specifically facilitates the efflux of cholesterol and phospholipids from cells to extracellular acceptors such as apolipoprotein A-I (APOA1), playing a crucial role in the formation of high-density lipoprotein (HDL) particles. This process is essential for reverse cholesterol transport (RCT), which helps remove excess cholesterol from tissues and prevents atherosclerosis. Mutations in the ABCA1 gene can lead to Tangier disease, a rare genetic disorder characterized by extremely low levels of HDL cholesterol and cholesterol accumulation in tissues.

免疫印迹
- WB result of ABCA1 Recombinant Rabbit mAb
  Primary antibody: ABCA1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: HCT 116 whole cell unboiled RIPA lysate 20 µg
  Lane 2: untreated HepG2 whole cell unboiled RIPA lysate 20 µg
  Lane 3: HepG2 treated with 20 μM T0901317 for 16 hours whole cell unboiled RIPA lysate 20 µg
  Lane 4: U-87 MG whole cell unboiled RIPA lysate 20 µg
  Negative control: HCT 116 whole cell unboiled RIPA lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 254 kDa
  Observed MW: 300 kDa
- WB result of ABCA1 Recombinant Rabbit mAb
  Primary antibody: ABCA1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: mouse liver unboiled RIPA lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 254 kDa
  Observed MW: 300 kDa
  This blot was developed with high sensitivity substrate
- WB result of ABCA1 Recombinant Rabbit mAb
  Primary antibody: ABCA1 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: rat brain unboiled RIPA lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 254 kDa
  Observed MW: 290 kDa
  This blot was developed with high sensitivity substrate