所有图片（1/3）

Nucleostemin Recombinant Rabbit mAb (S-1888-40)

Guanine nucleotide-binding protein-like 3,E2-induced gene 3 protein,Novel nucleolar protein 47 (NNP47),Nucleolar GTP-binding protein 3,E2IG3,NS,GNL3

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1453

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

Nucleostemin
分子别名

Guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; Novel nucleolar protein 47 (NNP47); Nucleolar GTP-binding protein 3; E2IG3; NS; GNL3
免疫原

Synthetic Peptide
细胞定位

Nucleus
Accession

Q9BVP2
克隆号

S-1888-40
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
阳性样本

HeLa, Jurkat, Raji, NIH/3T3, C6
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms, Rt

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms, Rt

背景介绍

Nucleostemin (NS), also known as guanine nucleotide-binding protein-like 3 (GNL3), is a nucleolar GTP-binding protein predominantly found in the nucleoli of stem cells, transformed cell lines, and various tumor cells. Initially identified in rat neural stem cells, NS is highly conserved across species and plays a crucial role in cell-cycle progression. It regulates cell proliferation by modulating ribosomal biogenesis and interacting with the p53-MDM2 feedback loop. Interestingly, both overexpression and depletion of NS can activate p53, suggesting its dual role in cellular homeostasis. Additionally, NS levels decrease as cells differentiate, making it a potential marker for stem cells and cancer cells. Its unique functions in ribosome assembly and cell-cycle regulation highlight its importance in both normal development and tumorigenesis.