大包装询价 产品介绍 评论(0)
宿主来源
Human抗原名称
Claudin 18.2分子别名
Claudin-18; CLDN18细胞定位
Cell membraneAccession
P56856-2克隆号
S-R700抗体类型
Recombinant mAb抗体同种型
IgG1,k反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
Claudin 18.2 monoclonal antibodies are a promising class of therapeutic agents targeting the Claudin 18.2 protein, a tight junction protein that is highly expressed in various cancers, including gastric, pancreatic, and ovarian cancers. In normal tissues, Claudin 18.2 is predominantly expressed in differentiated gastric mucosal cells, but its upregulation in tumor cells makes it an attractive target for cancer therapy. These monoclonal antibodies, such as Zolbetuximab, work by binding specifically to the extracellular domain of Claudin 18.2, inducing antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) to kill cancer cells.
评论(0)