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TGFBR2 Recombinant Rabbit mAb (S-1711-55)

TGF-beta receptor type-2,TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II (TGF-beta receptor type II,TbetaR-II)

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1432

规格

25μl100μl1ml

数量

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产品规格

宿主来源

Rabbit
抗原名称

TGFBR2
分子别名

TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II (TGF-beta receptor type II; TbetaR-II)
免疫原

Synthetic Peptide
细胞定位

Cell membrane, Secreted
Accession

P37173
克隆号

S-1711-55
抗体类型

Recombinant mAb
抗体同种型

IgG
应用

IHC-P ? ,
WB
反应种属 ?

Hu, Ms
阳性样本

NIH/3T3
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms
IHC-P	1:250	Hu

背景介绍

TGFBR2, also known as transforming growth factor-beta receptor type 2, is a transmembrane protein that plays a crucial role in cellular signaling. It contains a protein kinase domain and forms a heterodimeric complex with TGF-beta receptor type-1, binding to TGF-beta ligands to initiate signal transduction. This receptor complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes involved in cell proliferation, differentiation, apoptosis, wound healing, and immunosuppression. TGFBR2 is essential for maintaining cellular homeostasis and preventing uncontrolled cell growth, thus acting as a tumor suppressor. Mutations in the TGFBR2 gene are associated with various disorders, including Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and familial thoracic aortic aneurysm and dissection. Additionally, aberrations in TGFBR2 signaling are implicated in the development of multiple types of tumors.

免疫印迹
- WB result of TGFBR2 Recombinant Rabbit mAb
  Primary antibody: TGFBR2 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: HepG2 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 65 kDa
  Observed MW: 85-90 kDa
- WB result of TGFBR2 Recombinant Rabbit mAb
  Primary antibody: TGFBR2 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: Neuro-2a whole cell lysate 20 µg
  Lane 2: NIH/3T3 whole cell lysate 20 µg
  Negative control: Neuro-2a whole cell lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 65 kDa
  Observed MW: 60-90 kDa
免疫组化
- IHC shows positive staining in paraffin-embedded human liver. Anti-TGFBR2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human placenta. Anti-TGFBR2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human hepatocellular carcinoma. Anti-TGFBR2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
- Expression of TGFBR2 in tumor tissue.
- Expression of TGFBR2 in human tissue.