GPR64 Recombinant Rabbit mAb (S-1919-10)

Adhesion G-protein coupled receptor G2,G-protein coupled receptor 64,Human epididymis-specific protein 6 (He6),ADGRG2

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1399

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

GPR64
分子别名

Adhesion G-protein coupled receptor G2; G-protein coupled receptor 64; Human epididymis-specific protein 6 (He6); ADGRG2
免疫原

Synthetic Peptide
细胞定位

Apical cell membrane
Accession

Q8IZP9
克隆号

S-1919-10
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

IHC-P ?

IF ?
稀释度

应用稀释度推荐种属

IHC-P 1:500 Hu
IF 1:500 Hu

应用	稀释度	推荐种属
IHC-P	1:500	Hu
IF	1:500	Hu

背景介绍

GPR64, also known as Adhesion G protein-coupled receptor G2 (ADGRG2) or Human Epididymis-specific protein 6 (HE6), is a member of the adhesion G protein-coupled receptor (aGPCR) family and is primarily recognized for its role in male fertility. It is predominantly expressed in the epididymis and parathyroid gland, where it helps maintain ion/pH homeostasis and is involved in sperm maturation and fluid reabsorption. Recent studies have also identified GPR64 in other tissues, such as gastrointestinal tuft cells, where it may play a role in chemosensory functions. Additionally, GPR64 has been implicated in various cancers, including endometrial cancer and Ewing sarcoma, where it may influence tumor growth and metastasis. Despite its diverse functions, the exact mechanisms of GPR64 signaling remain under investigation, with ongoing research aiming to optimize peptide ligands for better receptor characterization.

免疫组化
- IHC shows positive staining in paraffin-embedded human epididymis. Anti-GPR64 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- Negative control: IHC shows negative staining in paraffin-embedded human testis. Anti-GPR64 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
免疫荧光
- IF shows positive staining in paraffin-embedded Human epididymis. Anti-GPR64 antibody was used at 1/500 dilution (Green) and incubated overnight at 4°C. Goat polyclonal Antibody to Rabbit IgG - H&L (Alexa Fluor® 488) was used as secondary antibody at 1/1000 dilution. Counterstained with DAPI (Blue). Heat mediated antigen retrieval with EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
组织表达图谱
- Expression of GPR64 in tumor tissue.
- Expression of GPR64 in human tissue.