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IKKβ Recombinant Rabbit mAb (S-1147-227)

Inhibitor of nuclear factor kappa-B kinase subunit beta,I-kappa-B-kinase beta,IKK-B,IKK-beta,IkBKB,I-kappa-B kinase 2 1 publication,IKK-2 1,IKK2 1 publication,Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB),Serine/threonine protein kinase IKBKB

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1387

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 引用文献(1) 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

IKKβ
分子别名

Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2 1 publication; IKK-2 1; IKK2 1 publication; Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB); Serine/threonine protein kinase IKBKB
免疫原

Synthetic Peptide
细胞定位

Cytoplasm, Nucleus
Accession

O14920
克隆号

S-1147-227
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
阳性样本

HeLa, K562, Jurkat, NIH/3T3, PC-12
纯化方式

Protein A
浓度

2 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms, Rt

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms, Rt

背景介绍

IKKβ, also known as IκB kinase β or IKK2, is a key regulatory kinase responsible for the activation of NF-κB through phosphorylation at specific serine residues. It is a crucial component of the IKK complex, which includes IKKα, IKKβ, and the regulatory subunit IKKγ (NEMO). Dysregulation of IKKβ activity has been implicated in several cancer types, where it contributes to cancer cell survival, proliferation, invasion, angiogenesis, and metastasis. Targeting IKKβ has emerged as a promising strategy for cancer therapy, with several inhibitors being developed and some advancing to clinical trials.

免疫印迹
- WB result of IKKβ Recombinant Rabbit mAb
  Primary antibody: IKKβ Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: HeLa whole cell lysate 20 µg
  Lane 2: K562 whole cell lysate 20 µg
  Lane 3: Jurkat whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 87 kDa
  Observed MW: 90 kDa
- WB result of IKKβ Recombinant Rabbit mAb
  Primary antibody: IKKβ Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: NIH/3T3 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 87 kDa
  Observed MW: 90 kDa
- WB result of IKKβ Recombinant Rabbit mAb
  Primary antibody: IKKβ Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: PC-12 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 87 kDa
  Observed MW: 90 kDa