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宿主来源
Mouse抗原名称
Feline CD4分子别名
T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P79355克隆号
S-1151-76抗体类型
Mouse mAb抗体同种型
IgG2b,k应用
ELISA反应种属 ?
Ct纯化方式
Protein A浓度
5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
CD4 is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR) and is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It is a member of the immunoglobulin superfamily and has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell. The D1 domain of CD4 interacts with the β2-domain of MHC class II molecules, allowing T cells displaying CD4 to be specific for antigens presented by MHC II. The cytoplasmic tail of CD4 contains a sequence of amino acids that allow it to recruit and interact with the tyrosine kinase Lck, which is crucial for T cell activation. CD4 is also the receptor for HIV, which uses the protein to gain entry into host T-cells through its viral envelope protein gp120.
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