CD57 Mouse mAb (S-R571)
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1,Beta-1,3-glucuronyltransferase 1,Glucuronosyltransferase P (GlcAT-P),UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (GlcUAT-P),B3GAT1,GLCATP,HNK-1,Leu-7
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宿主来源
Mouse抗原名称
CD57分子别名
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P (GlcAT-P); UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase (GlcUAT-P); B3GAT1; GLCATP; HNK-1; Leu-7细胞定位
Golgi apparatus membraneAccession
Q9P2W7克隆号
S-R571抗体类型
Mouse mAb反应种属 ?
Hu浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
应用
IHC-P ?
稀释度
应用 稀释度 推荐种属 IHC-P 1:500-1:1500 Hu
CD57 (also known as HNK-1 or LEU-7) is an 110 kDa glycoprotein predominantly expressed on natural killer (NK) cells, terminally differentiated CD8+ T cells, some monocytes, and neural crest cells. In the immune system, CD57 expression is associated with cellular senescence and terminal differentiation, characterized by reduced proliferative capacity but enhanced cytotoxicity. In NK cells, CD57 marks a more mature phenotype with higher cytotoxicity and responsiveness to signals from CD16 and natural cytotoxicity receptors (NCRs). Additionally, CD57 plays a role in the nervous system, where it is involved in neural crest cell migration and invasion, and is associated with metastasis in melanoma. Clinically, CD57 is used as a diagnostic marker for neuroendocrine and nervous system tumors.
免疫组化
IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human stomach. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human thyroid cancer. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human ovarian cancer. Anti-CD57 antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
FAQs
我们一般不推荐客户回收利用抗体。 因为抗体使用之后缓冲体系已经发生改变，不同客户在回收抗体的保存条件上也会有差异，所以抗体回收使用效果无法保证。另外，我们对一批抗体回收验证测试，测试结果显示不同抗体可回收次数不同，一般效价越高的抗体，可重复使用的次数越多，客户可根据实验情况来确定
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