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宿主来源
Rat抗原名称
Mouse CD335分子别名
Natural cytotoxicity triggering receptor 1; Activating receptor 1 (mAR-1); Lymphocyte antigen 94; Natural killer cell p46-related protein (NK-p46; NKp46; mNKp46); Ncr1; Ly94细胞定位
Cell membraneAccession
Q8C567克隆号
S-R613抗体类型
Rat mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Ms |
CD335, also known as NKp46, is a 46kDa natural cytotoxicity receptor that belongs to the immunoglobulin superfamily, with two extracellular Ig-like domains. It is selectively expressed on resting and activated natural killer (NK) cells, a subset of T lymphocytes, and certain innate lymphoid cells (ILCs), including ILC1 and a subset of NCR+ ILC3 in the mucosa. CD335 plays a crucial role in the lysis of autologous, allogeneic, or xenogeneic cells by NK cells and is highly conserved in mammals. The receptor's expression and function are vital for maintaining immune balance and defense capabilities, and it may also be involved in other immune cell subsets, suggesting its potential as a target for new immunotherapy strategies.
流式分析
Flow cytometric analysis of C57BL/6 mouse splenocytes labelling mouse CD335 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with NK1.1 - Alexa Fluor® 647 antibody separately.
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