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宿主来源
Mouse抗原名称
Mouse IL-17A分子别名
Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8); Il17a; Ctla8; Il17细胞定位
SecretedAccession
Q62386克隆号
S-R544抗体类型
Mouse mAb反应种属 ?
Ms, Rt纯化方式
Protein G浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
应用
in vivo IL-17A neutralization稀释度
IL-17A, also known as CTLA-8, is a significant member of the IL-17 cytokine family. It is primarily secreted by Th17 cells, but is also produced by various immune cells including CD8+ T cells, γδT cells, NKT cells, monocytes, and neutrophils. IL-17A plays a crucial role in host defense against a variety of bacterial and fungal pathogens and is also involved in allergic and autoimmune responses. It induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases, promoting neutrophilic inflammation and playing a role in antiviral responses. IL-17A is a homodimeric cytokine that binds with high affinity to IL-17RA, which is necessary for the biological activity of IL-17A. IL-17A is associated with multiple autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. In cancer, IL-17A also plays a pathogenic role by recruiting myeloid-derived suppressor cells (MDSCs) to suppress antitumor immunity and promoting tumor growth in vivo through the induction of IL-6. Therefore, IL-17A is an important target in the treatment of related diseases, as it plays a significant role in inflammation, immune responses, and tumor development.
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