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KDM5D Recombinant Rabbit mAb (S-1577-128)

Lysine-specific demethylase 5D,Histocompatibility Y antigen (H-Y),Histone demethylase JARID1D,Jumonji/ARID domain-containing protein 1D,Protein SmcY,[histone H3]-trimethyl-L-lysine(4) demethylase 5D,HY,HYA,JARID1D,KIAA0234,SMCY

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1249

规格

25μl100μl1ml

数量

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

KDM5D
分子别名

Lysine-specific demethylase 5D; Histocompatibility Y antigen (H-Y); Histone demethylase JARID1D; Jumonji/ARID domain-containing protein 1D; Protein SmcY; [histone H3]-trimethyl-L-lysine(4) demethylase 5D; HY; HYA; JARID1D; KIAA0234; SMCY
免疫原

Synthetic Peptide
细胞定位

Nucleus
Accession

Q9BY66
克隆号

S-1577-128
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
阳性样本

TF-1
预测反应种属
(反应种属缩写表)

Cz
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

IHC-P ? ,
WB
稀释度

应用稀释度推荐种属

WB 1:1000 Hu
IHC-P 1:1000 Hu

应用	稀释度	推荐种属
WB	1:1000	Hu
IHC-P	1:1000	Hu

背景介绍

KDM5D, also known as JARID1D or SMCY, is a gene located on the Y chromosome that encodes a protein with zinc finger domains. This protein acts as a histone demethylase, specifically targeting H3K4me2/3 marks, which are associated with transcriptional activation. KDM5D plays a role in various biological processes, including the development and function of the male reproductive system. It has been implicated in the regulation of genes that control cell adhesion and immune response in cancer, with its upregulation potentially contributing to cancer progression and gender differences in tumor behavior. KDM5D is also associated with minor histocompatibility antigens, which can lead to graft rejection in transplant settings. Its dysfunction has been linked to spermatogenic failure, highlighting its importance in male fertility.

免疫印迹
- WB result of KDM5D Recombinant Rabbit mAb
  Primary antibody: KDM5D Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: HeLa whole cell lysate 20 µg
  Lane 2: TF-1 whole cell lysate 20 µg
  Negative control: HeLa whole cell lysate
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 174 kDa
  Observed MW: 174 kDa
免疫组化
- IHC shows positive staining in paraffin-embedded human colon. Anti-KDM5D antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human tonsil. Anti-KDM5D antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human colon cancer. Anti-KDM5D antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
组织表达图谱
- Expression of KDM5D in tumor tissue.
- Expression of KDM5D in human tissue.