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宿主来源
Rabbit抗原名称
Tau (phospho S396)分子别名
Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau (PHF-tau); MAPT; MAPTL; MTBT1免疫原
Synthetic Peptide细胞定位
CytoplasmAccession
P10636-8克隆号
S-1016-38抗体类型
Recombinant mAb抗体同种型
IgG应用
WB反应种属 ?
Hu, Ms阳性样本
Mouse brain预测反应种属
(反应种属缩写表)Theoretically reacts with most common species纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Ms |
Tau (phospho S396) refers to the phosphorylation of the tau protein at serine residue 396. Phosphorylation at S396 is associated with the physiological role of tau in synaptic plasticity, which is the dynamic modulation of synaptic connections and is thought to underlie learning and memory processes. Tau phosphorylation at S396 has been shown to regulate the interaction between protein kinase C binding protein 1 (PICK1) and GluA2, which is fundamental to AMPAR internalization, a key molecular mechanism of LTD. Phosphorylation at S396 also contributes to reduced tau-microtubule binding and is correlated with C-terminal tau cleavage and distinct conformational changes in the protein.
免疫印迹
WB result of Tau (phospho S396) Recombinant Rabbit mAb
Primary antibody: Tau (phospho S396) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: mouse brain lysate 5 µg
Lane 2: phosphatase treated mouse brain lysate 5 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 46 kDa
Observed MW: 50~100 kDa
斑点杂交
Dot blot result of Tau (phospho S396) Recombinant Rabbit mAb
Lane 1: Tau (S396) phospho peptide
Lane 2: Tau (S396) phospho peptide
Lane 2: Tau unmodified peptide
Primary antibody: Tau (phospho S396) Recombinant Rabbit mAb at 1/1000 dilution
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
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