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Rabbit抗原名称
CXCL10/IP-10分子别名
C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10); Small-inducible cytokine B10; INP10; SCYB10免疫原
Recombinant Protein细胞定位
SecretedAccession
P02778抗体类型
Polyclonal antibody抗体同种型
IgG应用
WB反应种属 ?
Hu纯化方式
Immunogen Affinity浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu |
CXCL10, also known as Interferon-gamma-induced protein 10 (IP-10), is a small molecular weight cytokine belonging to the CXC chemokine family. It is a pleiotropic molecule with multiple functions, including the ability to exert potent biological effects such as promoting chemotaxis of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation, and angiogenesis in infectious and inflammatory diseases and cancer. The involvement of CXCL10 and its receptor CXCR3 in the pathogenesis of many autoimmune diseases has been established, including organ-specific diseases (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease) and systemic diseases (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus). The role of CXCL10 in kidney diseases suggests that it is involved in the development of kidney diseases through the chemoattraction of inflammatory cells, promotion of cell growth, and vascular inhibition. Additionally, CXCL10 has been shown to be an important biomarker for disease severity and can serve as a prognostic indicator for various kidney diseases. CXCL10 is also associated with the occurrence, development, therapeutic efficacy, and prognosis of various tumors.
免疫印迹
WB result of CXCL10/IP-10 Rabbit pAb
Primary antibody: CXCL10/IP-10 Rabbit pAb at 1/1000 dilution
Lane 1: untreated THP-1 whole cell lysate 20 µg
Lane 2: THP-1 treated with 100 ng/ml PMA for 24 hours, then 10 pg/ml LPS for 24 hours and 20ng/ml IFN-γ for 24 hours, and 300ng/ml Brefeldin A for the last 4 hours whole cell lysate 20 µg
Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution Predicted MW: 11 kDa
Observed MW: 12 kDa
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