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宿主来源
Rat抗原名称
CSF1R分子别名
Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; CD115; Csf1r; Csfmr; Fms细胞定位
Cell membraneAccession
P09581克隆号
S-R562抗体类型
Rat mAb抗体同种型
Rat IgG2a,k反应种属 ?
Ms纯化方式
Protein G浓度
Lot specific* (generally 2 to 10 mg/ml)*纯度
>95% (Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
in vivo macrophage depletion ,in vitro CSF1R neutralization ,in vivo monocyte depletion ,ELISA ,WB稀释度
应用 稀释度 推荐种属 WB 1:1000 Ms
CSF1R, or Colony-Stimulating Factor 1 Receptor, also known as CD115 and M-CSF-R, is a transmembrane receptor that belongs to the type III protein tyrosine kinase receptor family. It is primarily expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. The natural ligands for CSF1R include CSF1 and IL-34, which directly affect the differentiation and proliferation of tissue macrophages and osteoclasts. CSF1R plays a role in various physiological processes, including regulating the proliferation of early hematopoietic progenitor cells and influencing many physiological processes involved in immunology, metabolism, fertility, and pregnancy. Additionally, CSF1R is involved in modulating the function of tumor-associated macrophages (TAMs), which can suppress tumor immunity. CSF1R also plays an important role in the central nervous system and neurological diseases.
验证数据
Macrophage depletion efficacy of S0B1139 in C57 mice
免疫印迹
WB result of Invivo anti-mouse CSF1R Recombinant mAb
Primary antibody: Invivo anti-mouse CSF1R Recombinant mAb at 1/1000 dilution
Lane 1: M-CSFR His Tag Protein, Mouse 1 µg
Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 109 kDa
Observed MW: 80~110 kDa
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