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Mouse抗原名称
CD41a分子别名
Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; ITGA2B; GP2B; ITGAB细胞定位
MembraneAccession
P08514克隆号
HIP8抗体类型
Mouse mAb抗体同种型
IgG1反应种属 ?
Hu阳性样本
human peripheral blood纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Hu
CD41, also known as Integrin α-IIb or GPαIIb, is a protein expressed on platelets and megakaryocytes. CD41 is a component of the platelet membrane glycoprotein complex and non-covalently associates with CD61 (Integrin β-3) to form the αIIbβ3 complex, which is an essential integrin in platelets. It plays a crucial role in platelet activation and aggregation, particularly during thrombus formation and hemostasis. In clinical practice, the detection of CD41 is essential for diagnosing and studying platelet-related diseases. For instance, immunostaining for CD41 can help identify micromegakaryocytes, which might be confused with primitive megakaryocytes or lymphocytes in Wright-Giemsa staining, leading to missed diagnoses. CD41 staining can significantly improve the detection rate of micromegakaryocytes, which is crucial for the diagnosis and therapeutic monitoring of certain hematological disorders.
流式分析
Flow cytometric analysis of human peripheral blood labelling Human CD41a antibody at 1/2000 (0.1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD42b - Alexa Fluor® 488 separately. Gated on total viable cells.
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