PGC1α Recombinant Rabbit mAb (S-1199-234)

PGC1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) is a transcriptional coactivator that plays a pivotal role in regulating energy metabolism and is implicated in various biological processes. PGC1α acts as a coactivator for several nuclear receptors and transcription factors, enhancing their transcriptional activity. It is involved in the regulation of genes that are crucial for adaptive thermogenesis and energy metabolism. PGC1α coordinates the expression of multiple genes involved in glucose and fatty acid metabolism, playing a significant role in metabolic reprogramming in response to dietary changes. It is also involved in the regulation of circadian rhythms and energy metabolism by activating RORA and RORC, which in turn control the oscillatory expression of clock genes such as ARNTL/BMAL1 and NR1D1. PGC1α has been considered a potential therapeutic target for treating type 2 diabetes, obesity, cardiomyopathy, and other metabolic disorders. PGC1α can suppress cholesterol synthesis and reduce serum cholesterol levels. It upregulates the expression of genes like Insig-1 and Insig-2, which inhibit cholesterol synthesis in cells like HepG2. It also promotes the transformation of cholesterol into bile acids, thereby affecting cholesterol metabolism and serum cholesterol levels. Moreover, PGC1α is a key regulator of mitochondrial biogenesis and function, which is crucial for energy production and cellular metabolism. It is involved in the adaptive response to changes in energy demand and nutrient availability.