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CCR8 Recombinant Rabbit mAb (S-1414-148)

C-C chemokine receptor type 8,C-C CKR-8,CC-CKR-8,CCR-8,CC chemokine receptor CHEMR1,CMKBRL2,Chemokine receptor-like 1 (CKR-L1),GPR-CY6 (GPRCY6),TER1,CDw198,CKRL1,CMKBR8

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B1045

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
抗原名称

CCR8
分子别名

C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1 (CKR-L1); GPR-CY6 (GPRCY6); TER1; CDw198; CKRL1; CMKBR8; CMKBRL2
免疫原

Synthetic Peptide
细胞定位

Cell membrane
Accession

P51685
克隆号

S-1414-148
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu, Ms
阳性样本

A431, HuT 78, mouse spleen, mouse thymus
预测反应种属
(反应种属缩写表)

Mk
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB

IP
稀释度

应用稀释度推荐种属

WB 1:1000 Hu, Ms
IP 1:50 Hu

应用	稀释度	推荐种属
WB	1:1000	Hu, Ms
IP	1:50	Hu

背景介绍

CCR8 (C-C motif chemokine receptor 8) is a chemokine receptor that plays a significant role in immune cell trafficking and is highly expressed on regulatory T cells (Tregs) in the tumor microenvironment. In the context of cancer, CCR8 is specifically highly expressed on Tregs within the tumor tissue, but is minimally expressed in peripheral blood and normal tissues, making it a specific biomarker for Tregs at the tumor site. Its signaling pathway is involved in the regulation of various solid tumors, such as gastric cancer, breast cancer, and colorectal cancer, among others. Therefore, CCR8 is considered a highly potential target for tumor immunotherapy.

免疫印迹
- WB result of CCR8 Recombinant Rabbit mAb
  Primary antibody: CCR8 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: A431 whole cell lysate 20 µg
  Lane 2: HuT 78 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 41 kDa
  Observed MW: 45 kDa
- WB result of CCR8 Recombinant Rabbit mAb
  Primary antibody: CCR8 Recombinant Rabbit mAb at 1/1000 dilution
  Lane 1: mouse thymus lysate 20 µg
  Lane 2: mouse spleen lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 41 kDa
  Observed MW: 45 kDa
免疫沉淀
- CCR8 Rabbit mAb at 1/50 dilution (1 µg) immunoprecipitating CCR8 in 0.4 mg HuT 78 whole cell lysate.
  Western blot was performed on the immunoprecipitate using CCR8 Rabbit mAb at 1/1000 dilution.
  Secondary antibody (HRP) for IP was used at 1/1000 dilution.
  Lane 1: HuT 78 whole cell lysate 20 µg (Input)
  Lane 2: CCR8 Rabbit mAb IP in HuT 78 whole cell lysate
  Lane 3: Rabbit monoclonal IgG IP in HuT 78 whole cell lysate
  Predicted MW: 41 kDa
  Observed MW: 45 kDa