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CCR8 Recombinant Rabbit mAb (S-1414-148)

C-C chemokine receptor type 8,C-C CKR-8,CC-CKR-8,CCR-8,CC chemokine receptor CHEMR1,CMKBRL2,Chemokine receptor-like 1 (CKR-L1),GPR-CY6 (GPRCY6),TER1,CDw198,CKRL1,CMKBR8

货号： S0B1045

Datasheet COA
  • 价格： ￥600
  • 规格：
  • 数量：
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产品介绍 评论(0)

产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    CCR8

  • 分子别名

    C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1 (CKR-L1); GPR-CY6 (GPRCY6); TER1; CDw198; CKRL1; CMKBR8; CMKBRL2

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Cell membrane

  • Accession

    P51685

  • 克隆号

    S-1414-148

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 应用

    WB, IP

  • 反应种属 ?

    Hu, Ms

  • 阳性样本

    A431, HuT 78, mouse spleen, mouse thymus

  • 预测反应种属
    (反应种属缩写表)

    Mk

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度 推荐种属
WB 1:1000 Hu, Ms
IP 1:50 Hu
背景介绍

  • CCR8 (C-C motif chemokine receptor 8) is a chemokine receptor that plays a significant role in immune cell trafficking and is highly expressed on regulatory T cells (Tregs) in the tumor microenvironment. In the context of cancer, CCR8 is specifically highly expressed on Tregs within the tumor tissue, but is minimally expressed in peripheral blood and normal tissues, making it a specific biomarker for Tregs at the tumor site. Its signaling pathway is involved in the regulation of various solid tumors, such as gastric cancer, breast cancer, and colorectal cancer, among others. Therefore, CCR8 is considered a highly potential target for tumor immunotherapy.

  • 免疫印迹

    • WB result of CCR8 Recombinant Rabbit mAb
      Primary antibody: CCR8 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: A431 whole cell lysate 20 µg
      Lane 2: HuT 78 whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 41 kDa
      Observed MW: 45 kDa

    • WB result of CCR8 Recombinant Rabbit mAb
      Primary antibody: CCR8 Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse thymus lysate 20 µg
      Lane 2: mouse spleen lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 41 kDa
      Observed MW: 45 kDa

  • 免疫沉淀

    • CCR8 Rabbit mAb at 1/50 dilution (1 µg) immunoprecipitating CCR8 in 0.4 mg HuT 78 whole cell lysate.
      Western blot was performed on the immunoprecipitate using CCR8 Rabbit mAb at 1/1000 dilution.
      Secondary antibody (HRP) for IP was used at 1/1000 dilution.
      Lane 1: HuT 78 whole cell lysate 20 µg (Input)
      Lane 2: CCR8 Rabbit mAb IP in HuT 78 whole cell lysate
      Lane 3: Rabbit monoclonal IgG IP in HuT 78 whole cell lysate
      Predicted MW: 41 kDa
      Observed MW: 45 kDa

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