Invivo anti-mouse NK1.1 Recombinant mAb
Killer cell lectin-like receptor subfamily B member 1B allele A,CD161 antigen-like family member B,Lymphocyte antigen 55b (Ly-55b),NKR-P1 34,Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B),CD161b,Klrb1b,Ly55b,Nkrp1b
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Invivo mouse IgG2a isotype control
规格：1mg
价格：￥900.00
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Mouse抗原名称
NK1.1分子别名
Killer cell lectin-like receptor subfamily B member 1B allele A; CD161 antigen-like family member B; Lymphocyte antigen 55b (Ly-55b); NKR-P1 34; Natural killer cell surface protein NKR-P1B allele SJL/BALB (NKR-P1B); CD161b; Klrb1b; Ly55b; Nkrp1b细胞定位
MembraneAccession
P27812克隆号
S-R480抗体类型
Mouse mAb抗体同种型
Mouse IgG2a, k反应种属 ?
Ms纯化方式
Protein A浓度
5 mg/ml纯度
>95% (Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
In vivo NK cell depletion稀释度
NK1.1 is a surface antigen that is expressed on the cell membrane as a disulfide-linked homodimer. It is also known as CD161 or Ly-55 and is encoded by the NKR-P1B/NKR-P1C gene. NK1.1 is primarily found on the surface of NK cells and NK-T cells in certain mouse strains, such as C57BL/6, FVB/N, and NZB, but not in AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 1291. The expression of NK1.1 has been associated with the lysis of tumor cells in vitro and the rejection of bone marrow allografts in vivo. Additionally, NK1.1 plays a role in NK cell activation, IFN-γ production, and cytotoxic granule release. In mouse models, NK1.1 is used as a marker for natural killer (NK) cells, which are a type of lymphocyte that plays a key role in the innate immune system. NK cells are capable of destroying target cells without prior sensitization and exhibit cytotoxicity towards certain tumor cells and cells infected with viruses. They are also involved in the regulation of antibody-producing B cells. NK1.1 is also sometimes used as a marker for a subset of T cells that have characteristics of both T cells and NK cells, known as NKT cells. These cells can recognize lipid antigens presented by CD1d, a molecule more commonly associated with antigen presentation to NK cells than to T cells.
验证数据
NK cell depletion efficacy of S0B0998 in C57 mice
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