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宿主来源
Mouse抗原名称
CD40分子别名
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5细胞定位
Secreted, Cell membraneAccession
P25942克隆号
S-R485抗体类型
Mouse mAb抗体同种型
IgG2b应用
FCM反应种属 ?
Hu纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| FCM | 1:200 |
CD40, also known as TNFRSF5, is a type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is primarily expressed on antigen-presenting cells such as B cells, dendritic cells, and monocytes, and plays a pivotal role in the regulation of immune responses. The interaction of CD40 with its ligand, CD40L (CD154), is crucial for T cell activation, B cell proliferation, and the induction of humoral immunity. CD40 signaling is also involved in the maturation of dendritic cells and the promotion of cell-mediated immunity. Additionally, CD40 has been implicated in the pathogenesis of various cancers and is considered a potential target for immunotherapeutic strategies.
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling CD40 antibody at 1/200 (1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD19 - Alexa Fluor® 647 separately. Gated on total viable cells.
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