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Rabbit抗原名称
LAIR1/CD305分子别名
Leukocyte-associated immunoglobulin-like receptor 1, mLAIR1免疫原
Recombinant Protein细胞定位
Cell membraneAccession
Q8BG84克隆号
S-283-241抗体类型
Recombinant mAb抗体同种型
IgG应用
WB反应种属 ?
Ms纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| WB | 1:1000 |
LAIR1 (Leukocyte-associated immunoglobulin-like receptor 1) is an immune checkpoint receptor that is broadly expressed on a variety of hematopoietic cells, including T cells, B cells, and natural killer cells. LAIR1 modulates the homeostatic functions of monocytes and interstitial lung macrophages by binding to collagen. LAIR1 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs). When it binds to its ligand, it can recruit Src homology phosphatase-1 (SHP-1), thereby transmitting an inhibitory signal that reduces immune responses. LAIR1 is expressed on immunosuppressive myeloid cells in the tumor microenvironment, supporting their immunosuppressive activity, which may contribute to tumor development. LAIR1 may also be involved in immune imbalances in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Its absence may lead to abnormal cell activation and uncontrolled inflammatory responses. LAIR1 is differentially expressed in certain hematopoietic and non-hematopoietic tumors, potentially participating in their development.
免疫印迹
WB result of LAIR1/CD305 Recombinant Rabbit mAb
Primary antibody: LAIR1/CD305 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: NIH/3T3 whole cell lysate 20 µg
Lane 2: RAW264.7 whole cell lysate 20 µg
Lane 3: mouse thymus lysate 20 µg
Lane 4: mouse spleen lysate 20 µg
Negative control: NIH/3T3 whole cell lysate
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 30 kDa
Observed MW: 38~45 kDa
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