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宿主来源
Rabbit抗原名称
ATOH1分子别名
Transcription factor ATOH1, Atonal bHLH transcription factor 1, Class A basic helix-loop-helix protein 14 (bHLHa14), Helix-loop-helix protein hATH-1 (hATH1), Protein atonal homolog 1, ATH1, BHLHA14免疫原
Synthetic Peptide细胞定位
NucleusAccession
Q92858克隆号
S-1301-11抗体类型
Recombinant mAb抗体同种型
IgG应用
WB反应种属 ?
Hu, Ms, Rt预测反应种属
(反应种属缩写表)Cz纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| WB | 1:1000 |
ATOH1 (Atonal homolog 1), also known as MATH1, is a pivotal transcription factor involved in neural development. ATOH1 plays a critical role in neuronal differentiation during neural development. It regulates the differentiation of neural progenitor cells into neurons, facilitating the formation and directed growth of neurons. By modulating the expression of neurodevelopmental genes, ATOH1 influences the fate determination and differentiation processes of neural progenitor cells. The expression of ATOH1 is intimately linked to the development of sensory organs within the inner ear, particularly those related to hearing and balance. Studies have shown that ATOH1 expression is upregulated in response to hair cell damage, making it a key gene in hair cell regeneration. Overexpression of ATOH1 can induce hair cell regeneration in the cochlear sensory epithelium and non-sensory epithelia. ATOH1 is also involved in cell regeneration in multiple systems. For instance, in the colon, ATOH1-secreting progenitor cells contribute to the regeneration of Lgr5+ stem cells, facilitating the repair of damaged colon tissue through mechanisms independent of the Lgr5+ stem cell lineage.
免疫印迹
WB result of ATOH1 Recombinant Rabbit mAb
Primary antibody: ATOH1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: Jurkat whole cell lysate 20 µg
Lane 2: T-47D whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 38 kDa
Observed MW: 36 kDaWB result of ATOH1 Recombinant Rabbit mAb
Primary antibody: ATOH1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: NIH/3T3 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 38 kDa
Observed MW: 36 kDaWB result of ATOH1 Recombinant Rabbit mAb
Primary antibody: ATOH1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: PC-12 whole cell lysate 20 µg
Lane 2: C6 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 38 kDa
Observed MW: 36 kDa
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