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DUSP6 Rabbit Polyclonal antibody

Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1,Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3,MKP-3),MKP3,PYST1

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B0781

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Rabbit
抗原名称

DUSP6
分子别名

Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP-3), MKP3, PYST1
免疫原

Synthetic Peptide
细胞定位

Cytoplasm
Accession

Q16828
抗体类型

Polyclonal antibody
抗体同种型

IgG
反应种属 ?

Hu, Ms, Rt
预测反应种属
(反应种属缩写表)

Bv
纯化方式

Immunogen Affinity
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

WB
稀释度

应用稀释度

WB 1:1000

应用	稀释度
WB	1:1000

背景介绍

DUSP6, also known as dual specificity phosphatase 6, is a key regulator in cellular signaling pathways. It plays a crucial role in regulating cellular signaling pathways, affecting cellular processes such as proliferation, differentiation, and apoptosis. DUSP6 functions as a tumor suppressor gene in certain cancers, such as esophageal squamous cell carcinoma, inhibiting tumor cell growth and spread through mechanisms like regulating the ERK pathway. It involves in bone diseases like osteoporosis, influencing osteoclast differentiation and apoptosis through the regulation of the ERK2/Smad2 signaling pathway. In esophageal squamous cell carcinoma research, DUSP6 is found to be expressed at low levels in esophageal cancer cell lines and tissues, with this low expression correlating with high methylation status of the DUSP6 gene. In osteoporosis research, the expression of DUSP6 is suppressed in cases of osteoporosis, which is associated with upstream regulators like miR-181a and downstream signaling pathways such as ERK2 and SMAD2.

免疫印迹
- WB result of DUSP6 Rabbit pAb
  Primary antibody: DUSP6 Rabbit pAb at 1/1000 dilution
  Lane 1: HeLa whole cell lysate 20 µg
  Lane 2: HepG2 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 42 kDa
  Observed MW: 40 kDa
- WB result of DUSP6 Rabbit pAb
  Primary antibody: DUSP6 Rabbit pAb at 1/1000 dilution
  Lane 1: NIH/3T3 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 42 kDa
  Observed MW: 40 kDa
- WB result of DUSP6 Rabbit pAb
  Primary antibody: DUSP6 Rabbit pAb at 1/1000 dilution
  Lane 1: PC-12 whole cell lysate 20 µg
  Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
  Predicted MW: 42 kDa
  Observed MW: 40 kDa