CD123 Recombinant Mouse mAb (S-R442)
CD123,gammaC,IL3RA,IL3R,IL-3 receptor subunit alpha,IL-3R subunit alpha,IL-3R-alpha,IL-3RA,Interleukin-2 receptor subunit gamma,IL-2 receptor subunit gamma,IL-2R subunit gamma,IL-2RG,p64,Interleukin-3 receptor subunit alpha
货号： S0B0778
- 价格： ￥600
- 规格：
- 数量：
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别名
CD123,gammaC,IL3RA,IL3R,IL-3 receptor subunit alpha,IL-3R subunit alpha,IL-3R-alpha,IL-3RA,Interleukin-2 receptor subunit gamma,IL-2 receptor subunit gamma,IL-2R subunit gamma,IL-2RG,p64,Interleukin-3 receptor subunit alpha宿主来源
Mouse抗原名称
CD123细胞定位
Cell membraneAccession
P26951克隆号
S-R442抗体类型
Mouse mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| FCM | 1:500 |
The CD123 protein, also known as the Interleukin-3 receptor subunit alpha (IL-3RA) or CD123, is a crucial component of the interleukin-3 (IL-3) receptor complex and belongs to the Type I cytokine receptor family, specifically the Class 5 subfamily. CD123 serves as the high-affinity receptor for IL-3, forming a heterodimeric receptor complex with the β chain (CSF2RB). This protein mediates the stimulatory effects of IL-3 on the proliferation and differentiation of various hematopoietic cells, including pluripotent hematopoietic stem cells and lineage-committed cells. CD123 is expressed on normal plasmacytoid dendritic cells, basophils, monocytes, and eosinophils, and is overexpressed in various hematologic malignancies. In clinical research, the expression of CD123 is associated with chemotherapy resistance and high-risk genetic alterations in certain leukemias, such as acute myeloid leukemia (AML).
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling CD123 antibody at 1/500 (1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with HLA-DR - Brilliant Violet 605 separately. Gated on total viable cells.
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