Invivo anti-mouse CD4 Recombinant mAb

T-cell surface glycoprotein CD4,T-cell differentiation antigen L3T4,T-cell surface antigen T4/Leu-3

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货号： S0B0690

大包装询价

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产品规格

宿主来源

Rat
抗原名称

CD4
分子别名

T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3
Accession

P06332
克隆号

GK1.5
抗体类型

Rat mAb
抗体同种型

Rat IgG2b,k
应用

in vivo CD4+ T cell depletion
反应种属 ?

Ms
纯化方式

Protein G
浓度

Lot specific* (generally 5 to 10 mg/ml)*
纯度

>95% Determined by SDS-PAGE
内毒素含量

<2EU/mg
标记

Unconjugated
性状

Liquid
缓冲体系

PBS pH6.5, containing no preservative
储存条件

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

背景介绍

CD4 is a protein found on the surface of certain immune cells, primarily T helper cells (also known as CD4+ T cells). CD4 stands for "cluster of differentiation 4" and is a glycoprotein that serves as a receptor for major histocompatibility complex (MHC) class II molecules, which are present on the surface of antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells. The primary function of CD4+ T cells is to orchestrate and regulate the immune response. They are crucial in activating other immune cells, including macrophages, cytotoxic T cells (CD8+ T cells), and B cells, to eliminate pathogens and infected cells. CD4+ T cells can be further classified into different subsets based on their function and the cytokines they produce, such as Th1, Th2, Th17, and regulatory T cells (Tregs). CD4 is also used as a marker for identifying and quantifying T helper cells in clinical settings. Decreased CD4 counts are often associated with immune suppression, such as in HIV/AIDS, where the virus specifically targets and destroys CD4+ T cells, leading to a decline in immune function. Monitoring CD4 counts is important in managing HIV/AIDS and assessing the immune status of patients.