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Invivo anti-human CD32 (FcγRIIA) Recombinant mAb

Low affinity immunoglobulin gamma Fc region receptor II-a,IgG Fc receptor II-a,CDw32,Fc-gamma RII-a (Fc-gamma-RIIa,FcRII-a),FCGR2A,FCG2,FCGR2A1,IGFR2

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B0689
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 分子别名

    Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a), FCGR2A, FCG2, FCGR2A1, IGFR2

  • Accession

    P12318

  • 克隆号

    IV.3

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    Mouse IgG2b,k

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    5 mg/ml

  • 纯度

    >95% (Determined by SDS-PAGE)

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, containing no preservative

  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;

    -20 °C for 3 months under sterile conditions;

    -80 °C for 24 months under sterile conditions.

    Please avoid repeated freeze-thaw cycles.

  • 应用

    in vivo FcγRIIA blockade in humanized mice

    in vitro FcγRIIA blockade

    FCM

    ELISA

背景介绍

  • FcγRIIA is a specific receptor for immunoglobulin G (IgG), belonging to the family of Fcγ receptors (FcγR). Among the FcγRs, FcγRIIA functions as an activating receptor. This receptor is primarily expressed on the membranes of immune cells, such as human platelets, and serves as a bridge between specific antibodies and effector cell functions, tightly linking humoral immunity with cellular immunity. FcγRIIA plays a crucial role in regulating IgG effects, as it can bind to monomeric and immune complex (IC) IgG. It can induce either activation or inhibition of functions, participating in driving antibody effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and/or antibody-dependent cellular phagocytosis (ADCP), as well as antigen presentation and the release of chemokines and cytokines. In autoimmune inflammatory diseases like systemic lupus erythematosus (SLE), the expression of FcγRIIA may exacerbate lupus nephritis and promote platelet activation.

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