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宿主来源
Rabbit分子别名
Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1 (FLK-1), Kinase insert domain receptor (KDR), Protein-tyrosine kinase receptor flk-1, CD309, KDR细胞定位
Cell membraneAccession
P35968克隆号
S-R400抗体类型
Recombinant mAb抗体同种型
IgG应用
IHC-P反应种属 ?
Hu纯化方式
Protein A浓度
0.5 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 |
|---|---|
| IHC-P | 1:100 |
VEGF Receptor 2 protein, also known as VEGFR-2 or Flk-1, is a receptor tyrosine kinase that plays a crucial role in angiogenesis, vascular development, and embryonic hematopoiesis. It is the main receptor for vascular endothelial growth factors (VEGFs), such as VEGFA, VEGFC, and VEGFD. VEGFR-2 is expressed widely, particularly in vascular endothelial cells and hemangioendotheliomas. It is localized in the endoplasmic reticulum and cell membrane. VEGFR-2 mediates the VEGF-induced proliferation, survival, migration, tube formation, and sprouting of endothelial cells, which are critical steps in angiogenesis and vascular development. The main function of VEGFR-2 is to regulate the growth and development of endothelial cells through signal transduction. This process involves dynamic interactions between various proteins and signaling pathways. Some of the major signaling pathways associated with VEGFR-2 include the PI3K-Akt, Ras-Raf-MEK-ERK, PKC-STAT3, and JAK2-STAT3 pathways.
免疫组化
IHC shows positive staining in paraffin-embedded human kidney. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human placenta. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human prostatic hyperplasia. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human ovarian cancer. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
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