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VEGF Receptor 2/FLK-1 Recombinant Rabbit mAb (S-R400)

Vascular endothelial growth factor receptor 2,VEGFR-2,Fetal liver kinase 1 (FLK-1),Kinase insert domain receptor (KDR),Protein-tyrosine kinase receptor flk-1,CD309,KDR

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B0682

规格

25μl100μl1ml

数量

产品介绍

产品介绍 FAQs 评论(0)

产品规格

宿主来源

Rabbit
分子别名

Vascular endothelial growth factor receptor 2, VEGFR-2, Fetal liver kinase 1 (FLK-1), Kinase insert domain receptor (KDR), Protein-tyrosine kinase receptor flk-1, CD309, KDR
细胞定位

Cell membrane
Accession

P35968
克隆号

S-R400
抗体类型

Recombinant mAb
抗体同种型

IgG
反应种属 ?

Hu
纯化方式

Protein A
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

IHC-P ?
稀释度

应用稀释度

IHC-P 1:100

应用	稀释度
IHC-P	1:100

背景介绍

VEGF Receptor 2 protein, also known as VEGFR-2 or Flk-1, is a receptor tyrosine kinase that plays a crucial role in angiogenesis, vascular development, and embryonic hematopoiesis. It is the main receptor for vascular endothelial growth factors (VEGFs), such as VEGFA, VEGFC, and VEGFD. VEGFR-2 is expressed widely, particularly in vascular endothelial cells and hemangioendotheliomas. It is localized in the endoplasmic reticulum and cell membrane. VEGFR-2 mediates the VEGF-induced proliferation, survival, migration, tube formation, and sprouting of endothelial cells, which are critical steps in angiogenesis and vascular development. The main function of VEGFR-2 is to regulate the growth and development of endothelial cells through signal transduction. This process involves dynamic interactions between various proteins and signaling pathways. Some of the major signaling pathways associated with VEGFR-2 include the PI3K-Akt, Ras-Raf-MEK-ERK, PKC-STAT3, and JAK2-STAT3 pathways.

免疫组化
- IHC shows positive staining in paraffin-embedded human kidney. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human placenta. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human prostatic hyperplasia. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
- IHC shows positive staining in paraffin-embedded human ovarian cancer. Anti- VEGF Receptor 2/FLK-1 antibody was used at 1/100 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.